A Receptor on Acid

Qiuyan Chen; John J G Tesmer

doi:10.1016/j.cell.2017.01.012

A Receptor on Acid

Cell. 2017 Jan 26;168(3):339-341. doi: 10.1016/j.cell.2017.01.012.

Authors

Qiuyan Chen¹, John J G Tesmer²

Affiliations

¹ The Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
² The Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: tesmerjj@umich.edu.

Abstract

Wacker et al. report the crystal structure of LSD in complex with one of its major targets in the brain, the 5-HT_2B receptor, the first such structure for any psychedelic drug. The results shed light on the molecular mechanisms underlying its ability to induce hallucinations with greater duration and potency than closely related compounds.

Publication types

Comment

MeSH terms

Brain / drug effects
Hallucinogens / pharmacology*
Lysergic Acid Diethylamide / analogs & derivatives*

Substances

Hallucinogens
Lysergic Acid Diethylamide

Grants and funding

R01 HL071818/HL/NHLBI NIH HHS/United States