Abstract
A new route for the synthesis of functional aqueous nanogels decorated with a controlled amount of surface-drafted isoeugenol molecules has been developed. Obtained nanogels exhibit two key functions: a) antibacterial activity against different oral pathogens and b) cell-adhesive and -growth-promoting properties. Functional nanogels can be potentially used as building blocks in the design of bioactive coatings on various implants preventing infections and accelerating tissue regeneration.
Keywords:
antibacterial properties; cell adhesion; gels; isoeugenol; oral pathogens.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Bacterial Adhesion / drug effects
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Bacterial Infections / prevention & control
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Candida albicans / drug effects
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Candidiasis / prevention & control
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Coated Materials, Biocompatible / chemistry*
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Coated Materials, Biocompatible / pharmacology
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Eugenol / analogs & derivatives*
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Eugenol / chemistry
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Eugenol / pharmacology
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Gels / chemistry*
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Gels / pharmacology
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Humans
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Mouth / microbiology
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacology
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Coated Materials, Biocompatible
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Gels
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Eugenol
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Polyethylene Glycols
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isoeugenol