Functional Isoeugenol-Modified Nanogel Coatings for the Design of Biointerfaces

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2497-2502. doi: 10.1002/anie.201609180. Epub 2017 Jan 27.

Abstract

A new route for the synthesis of functional aqueous nanogels decorated with a controlled amount of surface-drafted isoeugenol molecules has been developed. Obtained nanogels exhibit two key functions: a) antibacterial activity against different oral pathogens and b) cell-adhesive and -growth-promoting properties. Functional nanogels can be potentially used as building blocks in the design of bioactive coatings on various implants preventing infections and accelerating tissue regeneration.

Keywords: antibacterial properties; cell adhesion; gels; isoeugenol; oral pathogens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology
  • Bacteria / drug effects
  • Bacterial Adhesion / drug effects
  • Bacterial Infections / prevention & control
  • Candida albicans / drug effects
  • Candidiasis / prevention & control
  • Coated Materials, Biocompatible / chemistry*
  • Coated Materials, Biocompatible / pharmacology
  • Eugenol / analogs & derivatives*
  • Eugenol / chemistry
  • Eugenol / pharmacology
  • Gels / chemistry*
  • Gels / pharmacology
  • Humans
  • Mouth / microbiology
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Coated Materials, Biocompatible
  • Gels
  • Eugenol
  • Polyethylene Glycols
  • isoeugenol