Aryl sulfonyl isocyanates are important intermediates in organic synthesis. They are used as electrophilic reagents and easily react with nucleophiles to form amides, sulfonyl ureas, pyrrolidine derivatives, lactams, oxazolidinones, and so on. Although there are some reviews on the applications of isocyanates in chemistry, few are concerned about aryl sulfonyl isocyanates. This review focuses on recent advances related to aryl sulfonyl isocyanates in organic synthesis, mainly including three special characteristics. The mechanisms of the typical reactions are also discussed.