The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation

Haematologica. 2017 May;102(5):e191-e194. doi: 10.3324/haematol.2016.152017. Epub 2017 Jan 25.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Animals
  • Biomarkers
  • Humans
  • Mice
  • Neutrophil Activation / drug effects*
  • Neutrophil Activation / genetics*
  • Neutrophil Activation / immunology
  • Neutrophils / drug effects*
  • Neutrophils / immunology
  • Neutrophils / metabolism*
  • Piperidines
  • Protein Kinase Inhibitors / pharmacology*
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*
  • Respiratory Burst / drug effects
  • Respiratory Burst / genetics
  • Respiratory Burst / immunology
  • Triggering Receptor Expressed on Myeloid Cells-1 / genetics*
  • Triggering Receptor Expressed on Myeloid Cells-1 / metabolism

Substances

  • Biomarkers
  • Piperidines
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyrimidines
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1
  • ibrutinib
  • Adenine