Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition

Edison T Liu; Ewelina Bolcun-Filas; David S Grass; Cathleen Lutz; Steve Murray; Lenny Shultz; Nadia Rosenthal

doi:10.15252/embr.201643717

Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition

EMBO Rep. 2017 Feb;18(2):187-193. doi: 10.15252/embr.201643717. Epub 2017 Jan 24.

Authors

Edison T Liu¹, Ewelina Bolcun-Filas¹, David S Grass¹, Cathleen Lutz¹, Steve Murray¹, Lenny Shultz¹, Nadia Rosenthal¹

Affiliation

¹ The Jackson Laboratory, Bar Harbor, ME, USA.

Abstract

The mouse has been a major model system for biomedical research. Gene editing technologies will further increase its importance for studying the human condition and human diseases.

MeSH terms

Animals
CRISPR-Cas Systems*
Disease Models, Animal*
Genetic Engineering / methods
Genetic Engineering / trends*
Humans
Mice / genetics*

Abstract

MeSH terms

Grants and funding