Mutant RAS Calms Stressed-Out Cancer Cells

Kirsten L Bryant; Channing J Der

doi:10.1016/j.devcel.2017.01.005

Mutant RAS Calms Stressed-Out Cancer Cells

Dev Cell. 2017 Jan 23;40(2):120-122. doi: 10.1016/j.devcel.2017.01.005.

Authors

Kirsten L Bryant¹, Channing J Der²

Affiliations

¹ Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
² Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address: channing_der@med.unc.edu.

Abstract

Mutant RAS-driven cancers are infamously resistant to chemotherapeutics. Reporting in Cell, Grabocka and Bar-Sagi (2016) demonstrate that when subjected to stress, mutant KRAS-dependent lipid production leads to upregulated stress granule formation. This confers not only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor niche.

Publication types

Comment

MeSH terms

Cell Line, Tumor
Humans
Mutation
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins p21(ras) / genetics*
ras Proteins / genetics*

Substances

Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding