Abstract
New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines and a number of compounds showed moderate to high inhibition activities.
Keywords:
1,3,4-thiadiazoles anticancer activity; 1-thia-azaspiro[4.5]decane; thiazolopyrimidine; thioglycosides.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Carcinoma, Hepatocellular / drug therapy*
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Cell Line, Tumor
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Colorectal Neoplasms / drug therapy*
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Glycosylation
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HCT116 Cells
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Hep G2 Cells
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Humans
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Liver Neoplasms / drug therapy*
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Male
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Prostatic Neoplasms / drug therapy*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
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Thiadiazoles / chemical synthesis
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Thiadiazoles / chemistry
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Thiadiazoles / pharmacology*
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Thiazolidines / chemical synthesis*
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Thiazolidines / chemistry
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Thiazolidines / pharmacology
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Thioglycosides / chemical synthesis
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Thioglycosides / chemistry
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Thioglycosides / pharmacology
Substances
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Antineoplastic Agents
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Spiro Compounds
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Thiadiazoles
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Thiazolidines
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Thioglycosides
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1,3,4-thiadiazole