Accelerating the search for the missing proteins in the human proteome

Mark S Baker; Seong Beom Ahn; Abidali Mohamedali; Mohammad T Islam; David Cantor; Peter D Verhaert; Susan Fanayan; Samridhi Sharma; Edouard C Nice; Mark Connor; Shoba Ranganathan

doi:10.1038/ncomms14271

Accelerating the search for the missing proteins in the human proteome

Nat Commun. 2017 Jan 24:8:14271. doi: 10.1038/ncomms14271.

Authors

Affiliations

¹ Department of Biomedical Sciences, Faculty of Medicine &Health Sciences, Macquarie University, New South Wales 2109, Australia.
² Department of Chemistry &Biomolecular Sciences, Macquarie University, New South Wales 2109, Australia.
³ Department of Biology, Antwerp University, Antwerpen 2020, Belgium.
⁴ Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.

Abstract

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

Publication types

Review

MeSH terms

Chromosome Mapping / methods*
Chromosomes, Human / genetics
Databases, Protein*
Genome, Human / genetics
Humans
Proteogenomics / methods*
Proteogenomics / statistics & numerical data
Proteome / genetics*
Receptors, G-Protein-Coupled / genetics

Substances

Proteome
Receptors, G-Protein-Coupled