Changes in monoamines and their metabolite levels in substantia nigra of aged rats

Mech Ageing Dev. 1989 Sep;49(3):227-33. doi: 10.1016/0047-6374(89)90073-0.

Abstract

A decrease in the monoamine and monoamine metabolite contents in the substantia nigra of aged rats vs. controls has been found. Hence, it can be speculated that this decrease may play a role in the multiple alterations in dopaminergic functions observed in aged rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Biogenic Monoamines / metabolism*
  • Dopamine / metabolism
  • Male
  • Rats
  • Rats, Inbred Strains
  • Substantia Nigra / metabolism*

Substances

  • Biogenic Monoamines
  • Dopamine