Flavonoids from Erythrina schliebenii

Stephen S Nyandoro; Joan J E Munissi; Msim Kombo; Clarence A Mgina; Fangfang Pan; Amra Gruhonjic; Paul Fitzpatrick; Yu Lu; Bin Wang; Kari Rissanen; Máté Erdélyi

doi:10.1021/acs.jnatprod.6b00839

Flavonoids from Erythrina schliebenii

J Nat Prod. 2017 Feb 24;80(2):377-383. doi: 10.1021/acs.jnatprod.6b00839. Epub 2017 Jan 23.

Authors

Stephen S Nyandoro^{1

2}, Joan J E Munissi^{1

2}, Msim Kombo¹, Clarence A Mgina¹, Fangfang Pan³, Amra Gruhonjic⁴, Paul Fitzpatrick⁴, Yu Lu⁵, Bin Wang⁵, Kari Rissanen³, Máté Erdélyi^{2

6}

Affiliations

¹ Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam , P.O. Box 35061, Dar es Salaam, Tanzania.
² Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg SE-412 96, Sweden.
³ Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box. 35, FI-40014 University of Jyvaskyla, Finland.
⁴ Sahlgrenska Cancer Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.
⁵ Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute , Beijing 101149, People's Republic of China.
⁶ Swedish NMR Centre, University of Gothenburg , Gothenburg SE-405 30, Sweden.

PMID: 28112509
DOI: 10.1021/acs.jnatprod.6b00839

Abstract

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2-4), and nineteen known natural products (5-23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32-64 μg mL^-1 and 36.9-101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC₅₀ values of 13.0-290.6 μM (pure compounds) and 38.3 to >100 μg mL^-1 (crude extracts).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemistry
Antitubercular Agents / isolation & purification*
Antitubercular Agents / pharmacology
Drug Screening Assays, Antitumor
Erythrina / classification*
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology
Humans
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plant Roots / chemistry
Tanzania

Substances

Antitubercular Agents
Flavonoids