Two new Anti-TMV active chalconoid analogues from the root of Phyllanthus emblica

Nat Prod Res. 2017 Sep;31(18):2143-2148. doi: 10.1080/14786419.2017.1280487. Epub 2017 Jan 23.

Abstract

Two new chalconoid analogues, emblirol A (1) and B (2), along with three known ones (3-5), were isolated from the root of the Phyllanthus emblica L. Their structures were elucidated on the basis of spectral data. Compound 1 and 2 showed moderate anti-TMV activity with inhibition rates 79.6 and 62.1% at a concentration of 1 mg/mL, respectively.

Keywords: Phyllanthus emblica; anti-TMV; emblirol A; emblirol B.

MeSH terms

  • Chalcones / chemistry
  • Chalcones / isolation & purification*
  • Chalcones / pharmacology*
  • Dose-Response Relationship, Drug
  • Molecular Structure
  • Phyllanthus emblica / chemistry*
  • Plant Roots / chemistry
  • Tobacco Mosaic Virus / drug effects*

Substances

  • Chalcones
  • emblirol A
  • emblirol B