Minocycline-Induced Hyperpigmentation Mimicking Aortic Dissection

Tinera Buckley; Justin Lee; Keith E Gipson; Jonathan Earle

doi:10.1016/j.athoracsur.2016.07.062

Minocycline-Induced Hyperpigmentation Mimicking Aortic Dissection

Ann Thorac Surg. 2017 Feb;103(2):e121-e122. doi: 10.1016/j.athoracsur.2016.07.062.

Authors

Tinera Buckley¹, Justin Lee², Keith E Gipson², Jonathan Earle³

Affiliations

¹ Department of Pathology, Hartford Hospital, Hartford, Connecticut. Electronic address: tinera.buckley@gmail.com.
² Department of Anesthesiology, Hartford Hospital, Hartford, Connecticut; Department of Anesthesiology, University of Connecticut School of Medicine, Farmington, Connecticut.
³ Department of Pathology, Hartford Hospital, Hartford, Connecticut.

PMID: 28109368
DOI: 10.1016/j.athoracsur.2016.07.062

Abstract

Minocycline-induced hyperpigmentation of tissues has been documented previously, but extensive cardiovascular involvement is rarely described in literature. We report a case of marked cardiovascular hyperpigmentation resulting from approximately 4 years of minocycline exposure. We will highlight how intraoperative differentiation of minocycline-induced hyperpigmentation from more sinister causes of discoloration led to the appropriate surgical management.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / therapeutic use
Aortic Aneurysm / diagnosis*
Aortic Dissection / diagnosis*
Aortic Valve / pathology
Aortic Valve / surgery
Diagnosis, Differential
Heart Valve Prosthesis Implantation / methods*
Humans
Hyperpigmentation / chemically induced*
Hyperpigmentation / diagnosis
Intraoperative Complications / diagnosis
Male
Middle Aged
Minocycline / adverse effects*
Minocycline / therapeutic use
Mitral Valve / pathology
Mitral Valve / surgery
Rare Diseases
Risk Assessment

Substances

Anti-Bacterial Agents
Minocycline