A single-centre experience of Roux-en-Y enteric drainage for pancreas transplantation

Transpl Int. 2017 Apr;30(4):410-419. doi: 10.1111/tri.12920. Epub 2017 Mar 2.

Abstract

Exocrine drainage following pancreas transplantation can be achieved by drainage into the bladder or bowel, the latter typically by direct duodeno-jejunostomy; the use of Roux-en-Y enteric drainage is uncommon. We report a retrospective analysis of a single-centre experience of Roux-en-Y enteric drainage following pancreas transplantation. Over a 14-year period (2001-2015), 204 consecutive adult pancreas transplants were performed (96.6% simultaneous pancreas and kidney transplants), of which 26.0% were from donors after circulatory death (DCD). During a median follow-up of 67 months (range 13-183 months), 14 (6.9%) recipients experienced complications related to their enteric drainage. Complications during follow-up included early enteric anastomotic haemorrhage (five patients), non-anastomotic enteric bleeding (one patient), small bowel obstruction (four patients) and graft duodenal perforation (two within 6 weeks, five beyond 12 months). No recipient lost their graft as a direct result of complications related to enteric drainage. Patient and pancreas graft survival at 1 year was 99.0% and 94.0% and at 5 years 91.3% and 84.9%, respectively. We conclude that Roux-en-Y enteric drainage following pancreas transplantation is a safe and effective procedure and facilitates graft salvage in the event of graft duodenal perforation.

Keywords: Roux-en-Y; anastomotic haemorrhage; duodenal perforation; enteric drainage; pancreas transplant.

MeSH terms

  • Adult
  • Anastomosis, Roux-en-Y / methods*
  • Anastomosis, Surgical
  • Drainage / methods*
  • Female
  • Follow-Up Studies
  • Graft Rejection
  • Graft Survival
  • Humans
  • Immunosuppression Therapy
  • Kidney Transplantation / methods
  • Male
  • Middle Aged
  • Pancreas Transplantation / methods*
  • Postoperative Complications / surgery
  • Prospective Studies
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Young Adult