Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway

Acta Neuropathol. 2017 Mar;133(3):489-491. doi: 10.1007/s00401-017-1676-z. Epub 2017 Jan 20.

Authors

Fabian Szepanowski¹, Daniel M Donaldson², Hans-Peter Hartung², Anne K Mausberg^{2

3}, Christoph Kleinschnitz³, Bernd C Kieseier², Mark Stettner^{2

3}

Affiliations

¹ Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany. fabian.szepanowski@uni-duesseldorf.de.
² Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
³ Department of Neurology, Medical Faculty, University Duisburg-Essen, Essen, Germany.

PMID: 28108787
DOI: 10.1007/s00401-017-1676-z

No abstract available

Publication types

Letter

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology*
Dimethyl Fumarate / pharmacology*
Disease Models, Animal
Heme Oxygenase-1 / metabolism*
Malondialdehyde / metabolism
Membrane Proteins / metabolism*
Mice, Inbred C57BL
Muscle Strength / drug effects
Muscle Strength / physiology
NF-E2-Related Factor 2 / metabolism*
Nerve Regeneration / drug effects*
Nerve Regeneration / physiology
Neuroprotective Agents / pharmacology*
Recovery of Function / drug effects
Recovery of Function / physiology
Sciatic Nerve / drug effects
Sciatic Nerve / injuries
Sciatic Nerve / metabolism
Sciatic Nerve / pathology
Signal Transduction / drug effects

Substances

Anti-Inflammatory Agents
Membrane Proteins
NF-E2-Related Factor 2
Neuroprotective Agents
Nfe2l2 protein, mouse
Malondialdehyde
Heme Oxygenase-1
Hmox1 protein, mouse
Dimethyl Fumarate