All that is old does not wither: Conservation of outer kinetochore proteins across all eukaryotes?

Aruni P Senaratne; Ines A Drinnenberg

doi:10.1083/jcb.201701025

All that is old does not wither: Conservation of outer kinetochore proteins across all eukaryotes?

J Cell Biol. 2017 Feb;216(2):291-293. doi: 10.1083/jcb.201701025. Epub 2017 Jan 20.

Authors

Aruni P Senaratne^{1

2}, Ines A Drinnenberg³

Affiliations

¹ Institut Curie, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique UMR 3664, F-75005 Paris, France.
² Sorbonne Universités, University Pierre-and-Marie-Curie, F-75005 Paris, France.
³ Institut Curie, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique UMR 3664, F-75005 Paris, France ines.drinnenberg@curie.fr.

Abstract

The kinetochore drives faithful chromosome segregation in all eukaryotes, yet the underlying machinery is diverse across species. D'Archivio and Wickstead (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608043) apply sensitive homology predictions to identify proteins in kinetoplastids with similarity to canonical outer kinetochore proteins, suggesting some degree of universality in the eukaryotic kinetochore.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromosome Segregation
Eukaryota*
Kinetochores*
Proteins

Substances

Proteins