Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke

Anatoly V Skalny; Lydmila L Klimenko; Aliya A Turna; Maria N Budanova; Ivan S Baskakov; Marina S Savostina; Aksana N Mazilina; Anatoly I Deyev; Margarita G Skalnaya; Alexey A Tinkov

doi:10.1016/j.jtemb.2016.12.018

Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke

J Trace Elem Med Biol. 2017 Sep:43:142-147. doi: 10.1016/j.jtemb.2016.12.018. Epub 2017 Jan 6.

Affiliations

¹ All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russia; Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia; Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia; RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia. Electronic address: skalny3@gmail.com.
² Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia.
³ Institute of Professional Development of Federal Medical-Biological Agency of Russia, Volokolamskoe St., 30, 1, Moscow, 123182, Russia.
⁴ Clinical Hospital № 123 Federal Medical-Biological Agency of Russia, Odintsovo, Moscow Region, Russia.
⁵ Institute of Chemical Physics of N. N. Semenov of the Russian Academy of Sciences, Kosygina St., 4, Moscow, 119991, Russia; N. I. Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow, 117997, Russia.
⁶ RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia.
⁷ Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia; Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia; RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia; Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia.

PMID: 28108058
DOI: 10.1016/j.jtemb.2016.12.018

Abstract

The objective of the present study was to assess hormonal and trace element status in men suffering from acute ischemic stroke.

Methods: 21 acute ischemic stroke patients and 21 age- and body mass index-matched healthy volunteers were enrolled in the study. Serum trace elements were assessed using inductively coupled plasma mass spectrometry. Serum hormones and brain damage markers were estimated using enzyme-linked immunosorbent assay.

Results: Ischemic stroke patients are characterized by significantly higher levels of total and free triiodothyronine (T₃), anti-thyroid peroxidase antibodies (Anti-TPO-Ab), prolactin, and cortisol, whereas the level of thyroid stimulating hormone (TSH) was decreased. Serum B, Cu, Li, Mn, Ni, Pb, Se, V, and Zn in stroke significantly exceeded the control values, whereas the level of Co and Fe was decreased. Correlation analysis revealed a significant association between serum B and T₃, Anti-TPO-Ab, and iodine concentration; serum Li and Sr levels - with circulating TSH, free T3, and Anti-TPO-Ab; and V concentration - with total T₃ and I levels. The following positive relationships were also revealed: Co - TSH, Mn - free T₃, Zn - free T₃. Multiple linear regression demonstrated that Co, I, and Li were directly related to circulating TSH levels, whereas V concentration was negatively interrelated. In turn, only serum Li levels were characterized by a significant direct relationship with free T3 values.

Conclusion: Generally, the obtained data demonstrate that altered serum trace elements are associated with thyroid dysfunction in acute ischemic stroke patients. However, the causal relationship should be estimated.

Keywords: Boron; Brain ischemia; Iodine; Lithium; Stroke; Thyroid.

MeSH terms

Aged
Brain Ischemia / blood*
Estradiol / blood
Humans
Iodine / blood
Male
Middle Aged
Progesterone / blood
Stroke / blood*
Testosterone / blood
Thyrotropin / blood
Trace Elements / blood*
Triiodothyronine / blood

Substances

Trace Elements
Triiodothyronine
Testosterone
Progesterone
Estradiol
Thyrotropin
Iodine