3,4 Dihydroxycinnamic acid stimulates immune system function by modifying the humoral antibody response - An in vivo study

Cell Immunol. 2017 Apr:314:10-17. doi: 10.1016/j.cellimm.2017.01.006. Epub 2017 Jan 11.

Abstract

The immunomodulatory property of 3,4-Dihydroxy-cinnamic acid (DCA) was studied under the normal and cyclophosphamide induced immunosuppressive conditions in animal models. The immunomodulatory activity was evaluated by studying the haematological parameters, humoral antibody, based on the plaque forming cell count, the bone marrow cellularity, the α-esterase's producing active cells, delayed type hypersensitive assay, phagocytic index assays. The chemopreventive effect of DCA was determined by cyclophosphamide induced immunosuppression in animals. From the response, DCA exhibits significant immunomodulatory activity by enhancing the humoral immune response. The histopathological investigation revealed the protective effect of DCA against cyclophosphamide induced immunosuppression. From the result it is observed that the DCA boosts up the immune system activity in a positive manner.

Keywords: 3,4 Dihydroxy-cinnamic acid; Humoral antibody; Hypersensitivity; Immunomodulatory.

MeSH terms

  • Animals
  • Antibodies / blood
  • Bone Marrow Cells / drug effects*
  • Bone Marrow Cells / physiology
  • Cells, Cultured
  • Coumaric Acids / chemistry
  • Coumaric Acids / therapeutic use*
  • Cyclophosphamide / therapeutic use
  • Cytoprotection
  • Drug-Related Side Effects and Adverse Reactions / drug therapy*
  • Hypersensitivity, Delayed / drug therapy*
  • Immune System / drug effects*
  • Immunity, Humoral / drug effects*
  • Immunologic Factors / therapeutic use*
  • Immunosuppression Therapy
  • Male
  • Mice
  • Phagocytosis / drug effects

Substances

  • Antibodies
  • Coumaric Acids
  • Immunologic Factors
  • Cyclophosphamide