In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor

Francis T Hane; Tao Li; Peter Smylie; Raiili M Pellizzari; Jennifer A Plata; Brenton DeBoef; Mitchell S Albert

doi:10.1038/srep41027

In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor

Sci Rep. 2017 Jan 20:7:41027. doi: 10.1038/srep41027.

Authors

Francis T Hane^{1

2}, Tao Li¹, Peter Smylie¹, Raiili M Pellizzari^{1

2}, Jennifer A Plata^{1

2}, Brenton DeBoef³, Mitchell S Albert^{1

2

4}

Affiliations

¹ Department of Chemistry, Lakehead University, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
² Thunder Bay Regional Research institute, 980 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.
³ Department of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston RI 02881, USA.
⁴ Northern Ontario School of Medicine, 955 Oliver Rd., Thunder Bay ON P7B 5E1, Canada.

Abstract

The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Vessels / diagnostic imaging*
Bridged-Ring Compounds / analysis*
Contrast Media / analysis*
Imidazoles / analysis*
Magnetic Resonance Imaging / methods*
Rats
Xenon Isotopes / analysis*

Substances

Bridged-Ring Compounds
Contrast Media
Imidazoles
Xenon Isotopes
cucurbit(6)uril