A series of 7-O-substituted hesperetins was evaluated for degranulation-inhibiting activity in rat basophil leukaemia cells. 7-O-Methyl and 7-O-ethyl hesperetin exhibited potent anti-degranulation activity compared with the original hesperetin.
Keywords: 7-O-alkyl hesperetin; 7-O-ethyl hesperetin; 7-O-methyl hesperetin; Hesperetin; degranulation-inhibiting activity; structure–activity relationship.