(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine

Biol Psychiatry. 2017 Sep 1;82(5):e43-e44. doi: 10.1016/j.biopsych.2016.12.020. Epub 2016 Dec 23.

Authors

Chun Yang¹, Youge Qu¹, Masahito Abe², Dai Nozawa², Shigeyuki Chaki², Kenji Hashimoto³

Affiliations

¹ Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba.
² Taisho Pharmaceutical Co., Ltd. , Saitama, Japan.
³ Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba. Electronic address: hashimoto@faculty.chiba-u.jp.

PMID: 28104224
DOI: 10.1016/j.biopsych.2016.12.020

No abstract available

Publication types

Comparative Study
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents / pharmacology*
Depressive Disorder / drug therapy*
Disease Models, Animal
Dominance-Subordination
Inflammation / drug therapy
Ketamine / analogs & derivatives*
Ketamine / pharmacology*
Lipopolysaccharides
Male
Mice, Inbred C57BL
Stereoisomerism
Stress, Psychological / drug therapy
Time Factors

Substances

Antidepressive Agents
Lipopolysaccharides
Ketamine
6-hydroxynorketamine