A simple method for NMR t1 noise suppression

Huaping Mo; John S Harwood; Danzhou Yang; Carol Beth Post

doi:10.1016/j.jmr.2016.12.014

A simple method for NMR t₁ noise suppression

J Magn Reson. 2017 Mar:276:43-50. doi: 10.1016/j.jmr.2016.12.014. Epub 2016 Dec 29.

Authors

Huaping Mo¹, John S Harwood², Danzhou Yang³, Carol Beth Post³

Affiliations

¹ Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: hmo@purdue.edu.
² Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
³ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.

Abstract

t₁ noise appears as random or semi-random spurious streaks along the indirect t₁ (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t₁ noise. One of the significant contributing factors to t₁ noise is unwanted and semi-random F2 signal modulation during t₁ acquisition. As such, t₁ noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t₁ noise compared with conventional acquisition with the same amount of total acquisition time and resolution.

Keywords: 2D spectroscopy; Frequency fluctuation; NMR; NOESY; t(1) noise suppression.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Algorithms
Artifacts
Data Interpretation, Statistical
Humans
Muramidase / chemistry
Nitrogen / chemistry
Nuclear Magnetic Resonance, Biomolecular / methods*

Substances

Muramidase
Nitrogen

Abstract

Publication types

MeSH terms

Substances

Grants and funding