Abstract
Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.
MeSH terms
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Apoptosis / drug effects
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Cell Survival / drug effects
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HeLa Cells
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Humans
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Photochemotherapy*
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Photons*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Quantum Theory
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Salts / chemistry
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Salts / pharmacology
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Singlet Oxygen / chemistry
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology*
Substances
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Photosensitizing Agents
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Salts
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Small Molecule Libraries
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Singlet Oxygen