Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass

J Nat Prod. 2017 Mar 24;80(3):726-730. doi: 10.1021/acs.jnatprod.6b00896. Epub 2017 Jan 18.

Abstract

Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Screening Assays, Antitumor
  • Gastropoda / chemistry*
  • Hawaii
  • Humans
  • Marine Biology
  • Molecular Structure
  • Ovum / chemistry*
  • Oxazoles / chemistry
  • Oxazoles / isolation & purification*
  • Oxazoles / pharmacology

Substances

  • Oxazoles
  • ulapualide C
  • ulapualide D
  • ulapualide E