Determination of Elizabethkingia Diversity by MALDI-TOF Mass Spectrometry and Whole-Genome Sequencing

Emerg Infect Dis. 2017 Feb;23(2):320-323. doi: 10.3201/eid2302.161321.

Abstract

In a hospital-acquired infection with multidrug-resistant Elizabethkingia, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene analysis identified the pathogen as Elizabethkingia miricola. Whole-genome sequencing, genus-level core genome analysis, and in silico DNA-DNA hybridization of 35 Elizabethkingia strains indicated that the species taxonomy should be further explored.

Keywords: 16S rRNA; Elizabethkingia miricola; Elizabethkingia species; Etest; GOB-1; MALDI-TOF; antimicrobial resistance; bacteria; carbapenemase; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; multidrug resistance; nomenclature; nosocomial infections; septic arthritis; β-lactamase.

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Arthritis, Infectious / diagnosis
  • Arthritis, Infectious / microbiology
  • Bacterial Typing Techniques
  • Drug Resistance, Bacterial
  • Flavobacteriaceae / classification*
  • Flavobacteriaceae / drug effects
  • Flavobacteriaceae / genetics*
  • Flavobacteriaceae / isolation & purification
  • Flavobacteriaceae Infections / diagnosis
  • Flavobacteriaceae Infections / virology
  • Genome, Bacterial*
  • Humans
  • Male
  • Middle Aged
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*
  • Whole Genome Sequencing*

Substances

  • Antineoplastic Agents
  • RNA, Ribosomal, 16S