Abstract
Depolymerizing actin in the amygdala through nonmuscle myosin II inhibition (NMIIi) produces a selective, lasting, and retrieval-independent disruption of the storage of methamphetamine-associated memories. Here we report a similar disruption of memories associated with amphetamine, but not cocaine or morphine, by NMIIi. Reconsolidation appeared to be disrupted with cocaine. Unlike in the amygdala, methamphetamine-associated memory storage was not disrupted by NMIIi in the hippocampus, nucleus accumbens, or orbitofrontal cortex. NMIIi in the hippocampus did appear to disrupt reconsolidation. Identification of the unique mechanisms responsible for NMII-mediated, amygdala-dependent disruption of memory storage associated with the amphetamine class may enable induction of retrieval-independent vulnerability to other pathological memories.
© 2017 Briggs et al.; Published by Cold Spring Harbor Laboratory Press.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Analysis of Variance
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Anesthetics, Local / administration & dosage
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Anesthetics, Local / pharmacology
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Animals
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Brain / drug effects*
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Brain / metabolism
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Brain / ultrastructure
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Central Nervous System Stimulants / administration & dosage
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Central Nervous System Stimulants / pharmacology
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Cocaine / administration & dosage
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Cocaine / pharmacology
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Conditioning, Operant / drug effects
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Conditioning, Operant / physiology
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Dendritic Spines / drug effects
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Dendritic Spines / ultrastructure
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Green Fluorescent Proteins / genetics
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Green Fluorescent Proteins / metabolism
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Heterocyclic Compounds, 4 or More Rings / toxicity*
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Memory Disorders / chemically induced*
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Memory Disorders / metabolism
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Memory Disorders / pathology
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Mental Recall / drug effects*
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Methamphetamine / administration & dosage
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Microinjections
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Morphine Derivatives / administration & dosage
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Morphine Derivatives / pharmacology
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Myosin Type II / metabolism*
Substances
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Anesthetics, Local
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Central Nervous System Stimulants
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Heterocyclic Compounds, 4 or More Rings
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Morphine Derivatives
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Green Fluorescent Proteins
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blebbistatin
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Methamphetamine
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Myosin Type II
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Cocaine