The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells

Leuk Lymphoma. 2017 Aug;58(8):1985-1988. doi: 10.1080/10428194.2016.1272690. Epub 2017 Jan 16.

Authors

Jin-Song Yan^{1

2}, Yi-Dong Li³, Su-Hui Liu², Qian-Qian Yin¹, Xin-Yi Liu¹, Li Xia¹, Ying Lu¹

Affiliations

¹ a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
² b Department of Hematology of the Second Hospital of Dalian Medical University , Institute of Hematopoietic Stem Cell Transplantation of Dalian Medical University , Dalian , China.
³ c Department of Pathophysiology , Shanghai Second Military Medical University , Shanghai , China.

PMID: 28092997
DOI: 10.1080/10428194.2016.1272690

No abstract available

Publication types

Letter

MeSH terms

Animals
Carrier Proteins / genetics*
Carrier Proteins / metabolism
Cell Line, Tumor
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Core Binding Factor Alpha 2 Subunit / genetics
Core Binding Factor Alpha 2 Subunit / metabolism*
Disease Models, Animal
Gene Expression Regulation, Leukemic
Humans
Leukemia, Myeloid, Acute / diagnosis
Leukemia, Myeloid, Acute / genetics*
Membrane Proteins / genetics*
Membrane Proteins / metabolism
Mice
Mutation
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism*
Protein Binding
RUNX1 Translocation Partner 1 Protein / genetics
RUNX1 Translocation Partner 1 Protein / metabolism*
Response Elements
Thyroid Hormone-Binding Proteins
Thyroid Hormones / genetics*
Thyroid Hormones / metabolism
Translocation, Genetic*
Xenograft Model Antitumor Assays

Substances

Carrier Proteins
Core Binding Factor Alpha 2 Subunit
Membrane Proteins
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
RUNX1 protein, human
RUNX1T1 protein, human
Thyroid Hormones