Graphene Oxide Wrapped SiO2 /TiO2 Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Yoonsun Jang; Sojin Kim; Seungae Lee; Chang-Min Yoon; Inkyu Lee; Jyongsik Jang

doi:10.1002/chem.201605112

Graphene Oxide Wrapped SiO₂ /TiO₂ Hollow Nanoparticles Loaded with Photosensitizer for Photothermal and Photodynamic Combination Therapy

Chemistry. 2017 Mar 13;23(15):3719-3727. doi: 10.1002/chem.201605112. Epub 2017 Feb 14.

Authors

Yoonsun Jang¹, Sojin Kim¹, Seungae Lee², Chang-Min Yoon¹, Inkyu Lee¹, Jyongsik Jang¹

Affiliations

¹ School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul, 151-742, South Korea), Fax.
² Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL, 60208, USA.

PMID: 28090694
DOI: 10.1002/chem.201605112

Abstract

Graphene oxide (GO) enwrapped SiO₂ /TiO₂ hollow nanoparticles (GO-HNP) are synthesized by the Stöber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibility and high uniformity in diameter (ca. 50 nm). Furthermore, this nanoparticle shows λ=808 nm laser induced PpIX release properties (photoinduced "on-off" drug-release system). GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of PTT and PDT exhibits powerful anticancer properties. When cancer cells are treated with GO-HNP-PpIX and irradiated with both visible light and a NIR laser, the cell viability drops dramatically to 2.5 %, which is an anticancer effect approximately 13 times higher than that obtained in a previous study. Moreover, no significant cell damage has been observed under λ=808 nm laser irradiation. The GO-HNP-PpIX system suggests an external stimuli-responsive efficient anticancer treatment effect toward human breast cancer cells.

Keywords: antitumor agents; drug delivery; graphene; nanoparticles; sensitizers.