Miniaturized and integrated whole cell living bacterial sensors in field applicable autonomous devices

Clémence Roggo; Jan Roelof van der Meer

doi:10.1016/j.copbio.2016.11.023

Miniaturized and integrated whole cell living bacterial sensors in field applicable autonomous devices

Curr Opin Biotechnol. 2017 Jun:45:24-33. doi: 10.1016/j.copbio.2016.11.023. Epub 2017 Jan 11.

Authors

Clémence Roggo¹, Jan Roelof van der Meer²

Affiliations

¹ Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland.
² Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland. Electronic address: janroelof.vandermeer@unil.ch.

PMID: 28088093
DOI: 10.1016/j.copbio.2016.11.023

Abstract

Live-cell based bioreporters are increasingly being deployed in microstructures, which facilitates their handling and permits the development of instruments that could perform autonomous environmental monitoring. Here we review recent developments of on-chip integration of live-cell bioreporters, the coupling of their reporter signal to the devices, their longer term preservation and multi-analyte capacity. We show examples of instruments that have attempted to fully integrate bioreporters as their sensing elements.

Publication types

Review

MeSH terms

Bacteria* / classification
Bacteria* / genetics
Biosensing Techniques
Environmental Monitoring*
Genes, Reporter