Abstract
Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
MeSH terms
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Animals
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Boron Compounds / analysis*
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Boron Compounds / chemistry
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Cell Line
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Disease Models, Animal
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Fluorescent Dyes / analysis*
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Fluorescent Dyes / chemistry
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Humans
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Mice
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Mice, Transgenic
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Molecular Structure
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Neurons / metabolism*
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Neurons / pathology*
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Optical Imaging*
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Protein Aggregates*
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tau Proteins / analysis*
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tau Proteins / chemistry
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tau Proteins / metabolism
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Fluorescent Dyes
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Protein Aggregates
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tau Proteins