Emerging links between m6A and misregulated mRNA methylation in cancer

Genome Med. 2017 Jan 12;9(1):2. doi: 10.1186/s13073-016-0395-8.

Abstract

N 6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / metabolism
  • Animals
  • Humans
  • Methylation
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / chemistry
  • RNA, Messenger / metabolism*

Substances

  • RNA, Messenger
  • N-methyladenosine
  • Adenosine