Identification of early neurodegenerative change in presymptomatic spinocerebellar ataxia type 1: A diffusion tensor imaging study

Yeon Ji Yoo; Jeehae Oh

doi:10.1016/j.parkreldis.2016.12.031

Identification of early neurodegenerative change in presymptomatic spinocerebellar ataxia type 1: A diffusion tensor imaging study

Parkinsonism Relat Disord. 2017 Mar:36:109-110. doi: 10.1016/j.parkreldis.2016.12.031. Epub 2017 Jan 3.

Authors

Yeon Ji Yoo¹, Jeehae Oh²

Affiliations

¹ Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul, 06591, Republic of Korea. Electronic address: nugry@naver.com.
² Department of Rehabilitation Medicine, Graduate School, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul, 06591, Republic of Korea. Electronic address: jeehaeoh@gmail.com.

PMID: 28073679
DOI: 10.1016/j.parkreldis.2016.12.031

Abstract

We report a 41-year-old man of presymptomatic spinocerebellar ataxia type 1. Diffusion tensor imaging (DTI) verified decreased fractional anisotropy of cerebellar afferent and efferent pathways compared to 5 age-matched healthy controls while conventional MRI revealed normal brain. DTI was valuable in detection of early microstructural damage of cerebellar pathways.

Keywords: Diffusion tensor imaging; Spinocerebellar ataxia.

Publication types

Case Reports
Letter

MeSH terms

Adult
Diffusion Tensor Imaging* / methods
Humans
Male
Neurodegenerative Diseases / diagnostic imaging
Neurodegenerative Diseases / genetics
Spinocerebellar Ataxias / diagnostic imaging*
Spinocerebellar Ataxias / genetics