Cell Migration: Making the Waves

Jan Müller; Michael Sixt

doi:10.1016/j.cub.2016.11.035

Cell Migration: Making the Waves

Curr Biol. 2017 Jan 9;27(1):R24-R25. doi: 10.1016/j.cub.2016.11.035.

Authors

Jan Müller¹, Michael Sixt²

Affiliations

¹ Institute of Science and Technology Austria (IST Austria), am Campus 1, 3400 Klosterneuburg, Austria.
² Institute of Science and Technology Austria (IST Austria), am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: sixt@ist.ac.at.

PMID: 28073017
DOI: 10.1016/j.cub.2016.11.035

Abstract

Coordinated changes of cell shape are often the result of the excitable, wave-like dynamics of the actin cytoskeleton. New work shows that, in migrating cells, protrusion waves arise from mechanochemical crosstalk between adhesion sites, membrane tension and the actin protrusive machinery.

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MeSH terms

Actin Cytoskeleton*
Actins*
Cell Movement
Cell Shape
Cytoskeleton

Substances

Actins