BH3-Only Proteins in Health and Disease

J A Glab; G W Mbogo; H Puthalakath

doi:10.1016/bs.ircmb.2016.08.005

BH3-Only Proteins in Health and Disease

Int Rev Cell Mol Biol. 2017:328:163-196. doi: 10.1016/bs.ircmb.2016.08.005. Epub 2016 Sep 28.

Authors

J A Glab¹, G W Mbogo¹, H Puthalakath²

Affiliations

¹ Department of Biochemistry, La Trobe Institute of Molecular Science, La Trobe University, Kingsbury Drive, Melbourne, VIC, Australia.
² Department of Biochemistry, La Trobe Institute of Molecular Science, La Trobe University, Kingsbury Drive, Melbourne, VIC, Australia. Electronic address: H.puthalakath@latrobe.edu.au.

PMID: 28069133
DOI: 10.1016/bs.ircmb.2016.08.005

Abstract

BH3-only proteins are proapoptotic members of the broader Bcl-2 family, which promote cell death by directly or indirectly activating Bax and Bak. The expression of BH3-only proteins is regulated both transcriptionally and posttranscriptionally in a cell type-specific and a tissue-specific manner. Research over the last 20 years has provided significant insights into their roles in tissue homeostasis and various pathologies, which in turn has led to the development of novel therapeutics for numerous diseases. In this review, a snapshot of the progress over this period is given, including our current understanding of their regulation, mode of action, role in mammalian development, and pathology.

Keywords: BH3-only proteins; Bcl-2 family; apoptosis; disease; homeostasis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Disease*
Health*
Homeostasis
Humans
Proto-Oncogene Proteins / metabolism*

Substances

Proto-Oncogene Proteins