A new monoterpenoid indole alkaloid from Ochrosia elliptica

Abstract

A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2-5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC₅₀ values comparable to those of cisplatin.

Keywords: 10-methoxyakuammidine; Ochrosia elliptica; cytotoxicity; monoterpenoid indole alkaloid.