Abstract
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries.
Keywords:
Malvaceae; Sida rhombifolia; indoquinoline alkaloids; vasorelaxant activity.
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Antihypertensive Agents / chemistry*
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Antihypertensive Agents / isolation & purification
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Antihypertensive Agents / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Dose-Response Relationship, Drug
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Humans
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Malvaceae / chemistry*
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Mesenteric Arteries / drug effects
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Mesenteric Arteries / physiology
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology
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Phytochemicals / chemistry*
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Phytochemicals / isolation & purification
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Phytochemicals / pharmacology
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Rats
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Tissue Culture Techniques
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Vasodilator Agents / chemistry*
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology
Substances
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Alkaloids
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Antihypertensive Agents
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Coumarins
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Flavonoids
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Phenols
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Phytochemicals
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Plant Extracts
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Vasodilator Agents