Abstract
Hypertrophic scarring (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Numerous studies have reported that non-coding RNAs (ncRNAs) including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs) play important roles in HS formation. Exploring non-coding RNA-based methods to treat scar would be instrumental for devising new effective therapies against scar. J. Cell. Biochem. 118: 1965-1968, 2017. © 2017 Wiley Periodicals, Inc.
Keywords:
HYPERTROPHIC SCAR; NON-CODING RNAs; lncRNAs; miRNAs.
© 2017 Wiley Periodicals, Inc.
Publication types
-
Review
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Actins / genetics
-
Actins / metabolism
-
Cell Proliferation
-
Cicatrix, Hypertrophic / genetics
-
Cicatrix, Hypertrophic / metabolism
-
Cicatrix, Hypertrophic / pathology
-
Cicatrix, Hypertrophic / therapy*
-
Collagen / genetics
-
Collagen / metabolism
-
Extracellular Matrix / genetics
-
Extracellular Matrix / metabolism*
-
Extracellular Matrix / pathology
-
Fibroblasts / metabolism*
-
Fibroblasts / pathology
-
Gene Expression Regulation
-
Humans
-
MicroRNAs / genetics
-
MicroRNAs / metabolism*
-
RNA, Long Noncoding / genetics
-
RNA, Long Noncoding / metabolism
-
RNA, Long Noncoding / therapeutic use*
-
Signal Transduction
-
Transforming Growth Factor beta / genetics
-
Transforming Growth Factor beta / metabolism
Substances
-
ACTA2 protein, human
-
Actins
-
MicroRNAs
-
RNA, Long Noncoding
-
Transforming Growth Factor beta
-
Collagen