Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression

Jin Yang; Xiaoqun Gong; Lei Fang; Qi Fan; Lei Cai; Xiaodi Qiu; Bo Zhang; Jin Chang; Yi Lu

doi:10.1016/j.nano.2016.12.021

Potential of CeCl₃@mSiO₂ nanoparticles in alleviating diabetic cataract development and progression

Nanomedicine. 2017 Apr;13(3):1147-1155. doi: 10.1016/j.nano.2016.12.021. Epub 2017 Jan 6.

Authors

Jin Yang¹, Xiaoqun Gong², Lei Fang³, Qi Fan¹, Lei Cai¹, Xiaodi Qiu¹, Bo Zhang³, Jin Chang⁴, Yi Lu⁵

Affiliations

¹ Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Myopia Key Laboratory of Health PR China, Shanghai, China.
² School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China. Electronic address: gongxiaoqun@tju.edu.cn.
³ School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China.
⁴ School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China. Electronic address: jinchang@tju.edu.cn.
⁵ Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Myopia Key Laboratory of Health PR China, Shanghai, China. Electronic address: luyieent@126.com.

PMID: 28065730
DOI: 10.1016/j.nano.2016.12.021

Abstract

Cataract is a major cause of visual impairment for diabetic patients. It is imperative to develop efficient therapeutic agents against diabetic cataract (DC) because diabetes confers higher risk for complications after cataract surgery. We have previously reported the role of CeCl₃ loaded mesoporous silica (CeCl₃@mSiO₂) nanoparticles in reducing the oxidative stress of lens epithelial cells. However, the potential of CeCl₃@mSiO₂ in preventing diabetic cataract development remains unclear. In this study, we applied CeCl₃@mSiO₂ nanoparticles with a size of 87.6±8.9nm to streptozotocin-induced diabetic cataract rat model by intraperitoneal injection. Our results showed that CeCl₃@mSiO₂ efficiently ameliorated the progression of DC. Consistent with antioxidant effect of CeCl₃@mSiO₂in vitro, administration of CeCl₃@mSiO₂ significantly abrogated hyperglycemia-mediated upregulation of advanced glycation end products, lipid peroxidation and protein carbonylation in animal lens. Taken together, our study provides a potential nanodrug to manage the development of DC.

Keywords: CeCl(3)@mSiO(2); Diabetic cataract; Glutathione; Oxidative stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / administration & dosage
Antioxidants / therapeutic use*
Cataract / drug therapy*
Cataract / metabolism
Cataract / pathology
Cerium / administration & dosage
Cerium / therapeutic use*
Diabetes Complications / complications
Diabetes Complications / drug therapy*
Diabetes Complications / metabolism
Diabetes Complications / pathology
Diabetes Mellitus, Experimental / complications*
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Experimental / pathology
Disease Progression
Drug Carriers / chemistry
Glycation End Products, Advanced / metabolism
Lens, Crystalline / drug effects
Lens, Crystalline / metabolism
Lens, Crystalline / pathology
Lipid Peroxidation / drug effects
Male
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Oxidative Stress / drug effects
Porosity
Protein Carbonylation / drug effects
Rats
Rats, Wistar
Silicon Dioxide / chemistry*

Substances

Antioxidants
Drug Carriers
Glycation End Products, Advanced
Cerium
Silicon Dioxide
cerous chloride