Laboratory Evaluation of the Liver

Vet Clin North Am Small Anim Pract. 2017 May;47(3):539-553. doi: 10.1016/j.cvsm.2016.11.005. Epub 2017 Jan 4.

Abstract

Laboratory evaluation of the hepatobiliary system has an important role in the diagnosis, monitoring, and assessment of patients with hepatobiliary diseases. Serum liver enzyme activities can be divided into markers of hepatocellular injury and cholestasis. Liver function can be assessed in several ways, including assessment of synthetic capacity, measurement of ammonia, and measurement of bile acids. It is essential to have an understanding of the performance characteristics and limitations of these tests in order to use them appropriately. This article reviews the laboratory parameters commonly used to aid diagnosing hepatobiliary disorders in dogs and cats.

Keywords: Ammonia; Bile acids; Bilirubin; Hepatic enzymes; Liver disease.

Publication types

  • Review

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Biliary Tract Diseases / blood
  • Biliary Tract Diseases / diagnosis
  • Biliary Tract Diseases / etiology
  • Biliary Tract Diseases / veterinary*
  • Bilirubin / blood
  • Biomarkers
  • Cat Diseases / blood
  • Cat Diseases / diagnosis*
  • Cat Diseases / etiology*
  • Cats
  • Cholestasis / blood
  • Cholestasis / veterinary
  • Clinical Laboratory Techniques / veterinary
  • Dog Diseases / blood
  • Dog Diseases / diagnosis*
  • Dog Diseases / etiology*
  • Dogs
  • Liver
  • Liver Diseases / blood
  • Liver Diseases / diagnosis
  • Liver Diseases / etiology
  • Liver Diseases / veterinary*

Substances

  • Biomarkers
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Bilirubin