Exosomal Small Talk Carries Strong Messages from Muscle Stem Cells

Janelle M Spinazzola; Emanuela Gussoni

doi:10.1016/j.stem.2016.12.009

Exosomal Small Talk Carries Strong Messages from Muscle Stem Cells

Cell Stem Cell. 2017 Jan 5;20(1):1-3. doi: 10.1016/j.stem.2016.12.009.

Authors

Janelle M Spinazzola¹, Emanuela Gussoni²

Affiliations

¹ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
² Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: gussoni@enders.tch.harvard.edu.

PMID: 28061348
DOI: 10.1016/j.stem.2016.12.009

Abstract

Exosome-dependent intercellular communication is an emerging signaling mechanism involved in tissue repair and regeneration. Now in this issue of Cell Stem Cell, Fry et al. (2016) show that muscle stem cells communicate with fibrogenic cells by exosomal trafficking of microRNA-206 to regulate extracellular matrix deposition and muscle tissue remodeling.

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MeSH terms

Cell Communication*
Exosomes*
Humans
Myoblasts
Regeneration
Stem Cells