DNA-Origami-Driven Lithography for Patterning on Gold Surfaces with Sub-10 nm Resolution

Isaac Gállego; Brendan Manning; Joan Daniel Prades; Mònica Mir; Josep Samitier; Ramon Eritja

doi:10.1002/adma.201603233

DNA-Origami-Driven Lithography for Patterning on Gold Surfaces with Sub-10 nm Resolution

Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201603233. Epub 2017 Jan 6.

Authors

Isaac Gállego¹, Brendan Manning¹, Joan Daniel Prades², Mònica Mir³, Josep Samitier³, Ramon Eritja¹

Affiliations

¹ Institute for Advanced Chemistry of Catalonia (IQAC), Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spanish National Research Council (CSIC), Barcelona, 08034, Spain.
² MIND-IN2UB, Department of Engineering: Electronics, University of Barcelona, Barcelona, 08028, Spain.
³ Institute for Bioengineering of Catalonia (IBEC), Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, 08028, Spain.

PMID: 28060403
DOI: 10.1002/adma.201603233

Abstract

Sub-10 nm lithography of DNA patterns is achieved using the DNA-origami stamping method. This new strategy utilizes DNA origami to bind a preprogrammed DNA ink pattern composed of thiol-modified oligonucleotides on gold surfaces. Upon denaturation of the DNA origami, the DNA ink pattern is exposed. The pattern can then be developed by hybridization with complementary strands carrying gold nanoparticles.

Keywords: DNA nanotechnology; gold nanoparticles; lithography; metasurfaces; nanopatterning.