Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma

Taishi Nakamura; Satoshi Yamashita; Kazutaka Fukumura; Jun Nakabayashi; Kazuhiro Tanaka; Kaoru Tamura; Kensuke Tateishi; Manabu Kinoshita; Shintaro Fukushima; Hirokazu Takami; Kohei Fukuoka; Kai Yamazaki; Yuko Matsushita; Makoto Ohno; Yasuji Miyakita; Soichiro Shibui; Atsuhiko Kubo; Takashi Shuto; Sylvia Kocialkowski; Shoji Yamanaka; Akitake Mukasa; Takashi Sasayama; Kazuhiko Mishima; Taketoshi Maehara; Nobutaka Kawahara; Motoo Nagane; Yoshitaka Narita; Hiroyuki Mano; Toshikazu Ushijima; Koichi Ichimura

doi:10.1007/s00401-016-1664-8

Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma

Acta Neuropathol. 2017 Feb;133(2):321-324. doi: 10.1007/s00401-016-1664-8. Epub 2017 Jan 5.

Authors

Taishi Nakamura^{1

2}, Satoshi Yamashita³, Kazutaka Fukumura⁴, Jun Nakabayashi⁵, Kazuhiro Tanaka⁶, Kaoru Tamura⁷, Kensuke Tateishi⁸, Manabu Kinoshita⁹, Shintaro Fukushima¹⁰, Hirokazu Takami¹⁰, Kohei Fukuoka¹⁰, Kai Yamazaki¹⁰, Yuko Matsushita¹¹, Makoto Ohno¹¹, Yasuji Miyakita¹¹, Soichiro Shibui¹², Atsuhiko Kubo¹³, Takashi Shuto¹⁴, Sylvia Kocialkowski¹⁵, Shoji Yamanaka¹⁶, Akitake Mukasa¹⁷, Takashi Sasayama⁶, Kazuhiko Mishima¹⁸, Taketoshi Maehara⁷, Nobutaka Kawahara⁸, Motoo Nagane¹⁹, Yoshitaka Narita¹¹, Hiroyuki Mano⁴, Toshikazu Ushijima³, Koichi Ichimura⁸

Affiliations

¹ Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. n_taishi@yokohama-cu.ac.jp.
² Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. n_taishi@yokohama-cu.ac.jp.
³ Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
⁴ Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁵ Advanced Medical Research Center, Yokohama City University, Yokohama, Japan.
⁶ Department of Neurosurgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
⁷ Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
⁸ Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
⁹ Department of Neurosurgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
¹⁰ Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
¹¹ Department of Neurosurgery and Neuro-Oncology, National Cancer Center, Tokyo, Japan.
¹² Department of Neurosurgery, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
¹³ Department of Neurosurgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.
¹⁴ Department of Neurosurgery, Yokohama Rosai Hospital, Yokohama, Japan.
¹⁵ Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, Cambridgeshire, CB2 1QP, UK.
¹⁶ Department of Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
¹⁷ Departments of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
¹⁸ Department of Neuro-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
¹⁹ Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.

PMID: 28058506
DOI: 10.1007/s00401-016-1664-8

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Central Nervous System Neoplasms / genetics*
DNA Methylation
Gene Expression Profiling / methods
Humans
Lymphoma / genetics*
Lymphoma, Large B-Cell, Diffuse / genetics*