Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Bai Ji; Benjamin R E Harris; Yahui Liu; Yibin Deng; Sergio A Gradilone; Margot P Cleary; Jianhua Liu; Da-Qing Yang

doi:10.3390/ijms18010093

Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Int J Mol Sci. 2017 Jan 4;18(1):93. doi: 10.3390/ijms18010093.

Authors

Bai Ji^{1

2}, Benjamin R E Harris³, Yahui Liu⁴, Yibin Deng^{5

6}, Sergio A Gradilone^{7

8}, Margot P Cleary^{9

10}, Jianhua Liu¹¹, Da-Qing Yang^{12

13}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. bji@hi.umn.edu.
² The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. bji@hi.umn.edu.
³ The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. brharris@umn.edu.
⁴ Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. jirulin@sina.com.
⁵ The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. yideng@hi.umn.edu.
⁶ The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. yideng@hi.umn.edu.
⁷ The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. sgradilone@hi.umn.edu.
⁸ The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. sgradilone@hi.umn.edu.
⁹ The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. mpcleary@hi.umn.edu.
¹⁰ The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. mpcleary@hi.umn.edu.
¹¹ Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. jirulin@yeah.net.
¹² The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA. dyang@umn.edu.
¹³ The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. dyang@umn.edu.

Abstract

While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5'-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.

Keywords: DNA damage; IRES-trans acting factors (ITAFs); internal ribosome entry site (IRES); p53.

Publication types

Review

MeSH terms

5' Untranslated Regions
Animals
Carcinogenesis / genetics
DNA Damage*
Gene Expression Regulation, Neoplastic*
Humans
Internal Ribosome Entry Sites*
Neoplasms / diagnosis
Neoplasms / genetics*
Protein Biosynthesis
RNA, Messenger / genetics
Tumor Suppressor Protein p53 / genetics*

Substances

5' Untranslated Regions
Internal Ribosome Entry Sites
RNA, Messenger
Tumor Suppressor Protein p53

Abstract

Publication types

MeSH terms

Substances

Grants and funding