Use of a redox probe for an electrochemical RNA-ligand binding assay in microliter droplets

Chem Commun (Camb). 2017 Jan 17;53(6):1140-1143. doi: 10.1039/c6cc07785d.

Abstract

In this work, we report an affordable, sensitive, fast and user-friendly electroanalytical method for monitoring the binding between unlabeled RNA and small compounds in microliter-size droplets using a redox-probe and disposable miniaturized screen-printed electrochemical cells.

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Binding Sites
  • Electrochemical Techniques*
  • Ligands
  • Oxidation-Reduction
  • Particle Size
  • RNA / chemistry*
  • Small Molecule Libraries / chemistry*
  • Surface Properties

Substances

  • Aptamers, Nucleotide
  • Ligands
  • Small Molecule Libraries
  • RNA