Getting to the "Heart" of Cardiac Disease by Decreasing Mitochondrial Iron

Circ Res. 2016 Nov 11;119(11):1164-1166. doi: 10.1161/CIRCRESAHA.116.309746.

Abstract

Iron chelation rather than supplementation would be beneficial to patients with heart diseases. More effort should be devoted to the development of iron chelators that could target mitochondrial iron.

Keywords: anemia; heart failure; iron; mitochondria; myocardial reperfusion.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anemia, Iron-Deficiency / diagnosis
  • Anemia, Iron-Deficiency / metabolism
  • Anemia, Iron-Deficiency / therapy
  • Animals
  • Heart / physiology*
  • Heart Diseases / diagnosis
  • Heart Diseases / metabolism*
  • Heart Diseases / therapy
  • Humans
  • Iron / metabolism*
  • Iron Overload / diagnosis
  • Iron Overload / metabolism
  • Iron Overload / therapy
  • Mitochondria, Heart / metabolism*
  • Myocardial Reperfusion Injury / diagnosis
  • Myocardial Reperfusion Injury / metabolism
  • Myocardial Reperfusion Injury / therapy

Substances

  • Iron