Vancomycin therapy in secondary care; investigating factors that impact therapeutic target attainment

Timothy M Rawson; Esmita Charani; Luke S P Moore; Pau Herrero; Ji Soo Baik; Akash Philip; Mark Gilchrist; Eimear T Brannigan; Pantelis Georgiou; William Hope; Alison H Holmes

doi:10.1016/j.jinf.2016.12.011

Vancomycin therapy in secondary care; investigating factors that impact therapeutic target attainment

J Infect. 2017 Mar;74(3):320-324. doi: 10.1016/j.jinf.2016.12.011. Epub 2016 Dec 30.

Authors

Affiliations

¹ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom. Electronic address: tmr07@imperial.ac.uk.
² National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom. Electronic address: e.charani@imperial.ac.uk.
³ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom; Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, United Kingdom. Electronic address: l.moore@imperial.ac.uk.
⁴ Department of Electrical and Electronic Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address: p.herrero-vinias@imperial.ac.uk.
⁵ School of Medicine, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. Electronic address: ji.baik11@imperial.ac.uk.
⁶ Department of Electrical and Electronic Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address: akash.philip12@imperial.ac.uk.
⁷ Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, United Kingdom. Electronic address: mark.gilchrist@imperial.nhs.uk.
⁸ Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, United Kingdom. Electronic address: Eimear.brannigan@imperial.nhs.uk.
⁹ Department of Electrical and Electronic Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address: pantelis@imperial.ac.uk.
¹⁰ Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, United Kingdom. Electronic address: william.hope@liverpool.ac.uk.
¹¹ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom; Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS, United Kingdom. Electronic address: alison.holmes@imperial.ac.uk.

PMID: 28043826
DOI: 10.1016/j.jinf.2016.12.011

No abstract available

Keywords: Antimicrobial resistance; Obesity; Pharmacokinetic–pharmacodynamic; Population modelling; Vancomycin.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anti-Bacterial Agents
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Secondary Care*
Vancomycin*

Substances

Anti-Bacterial Agents
Vancomycin

Grants and funding

II-LA-0214-20008/DH_/Department of Health/United Kingdom