Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae)

Abdou Tchoukoua; Turibio Kuiate Tabopda; Shota Uesugi; Misa Ohno; Ken-Ichi Kimura; Eunsang Kwon; Hiroyuki Momma; Ibrahim Horo; Özgen Alankuş Çalişkan; Yoshihito Shiono; Bonaventure Tchaleu Ngadjui

doi:10.1016/j.phytochem.2016.12.019

Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae)

Phytochemistry. 2017 Apr:136:31-38. doi: 10.1016/j.phytochem.2016.12.019. Epub 2016 Dec 30.

Affiliations

¹ Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon; Faculty of Agriculture, Yamagata University, 1-23, Wakaba-machi, Tsuruoka, Yamagata, 997-8555, Japan.
² Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon. Electronic address: ttabopda@yahoo.fr.
³ Laboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan.
⁴ Laboratory of Chemical Biology, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan; Graduate School of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan.
⁵ Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, Miyagi 980-8578, Japan.
⁶ Department of Chemistry, Faculty of Science, Ege University, 35100, Bornova, İzmir, Turkey.
⁷ Faculty of Agriculture, Yamagata University, 1-23, Wakaba-machi, Tsuruoka, Yamagata, 997-8555, Japan. Electronic address: yshiono@tds1.tr.yamagata-u.ac.jp.
⁸ Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon; Department of Medicine and Traditional Pharmacopoeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, P.O. Box 1364, Yaoundé, Cameroon. Electronic address: ngadjuibt@yahoo.fr.

PMID: 28043655
DOI: 10.1016/j.phytochem.2016.12.019

Abstract

Seven previously undescribed bidesmosidic triterpenoid saponins named albidosides A - G, were isolated from a methanol extract of the roots of Acacia albida. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry and determined to be bidesmosides of oleanolic acid and of 16α-hydroxyoleanolic acid. Albidosides B - G were assayed for their cytotoxicity against HeLa and HL60 cells using MTT method and microscopic observation.

Keywords: Acacia albida; Cytotoxicity; Mimosaceae; Triterpene saponins.

MeSH terms

Acacia / chemistry*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cameroon
Drug Screening Assays, Antitumor
HL-60 Cells
HeLa Cells
Humans
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification
Oleanolic Acid / pharmacology
Plant Roots / chemistry
Saponins / chemistry
Saponins / isolation & purification*

Substances

Antineoplastic Agents, Phytogenic
Saponins
albidoside A
Oleanolic Acid