Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties

Natália Aparecida Liberto; Juliana Baptista Simões; Sarah de Paiva Silva; Cristiane Jovelina da Silva; Luzia Valentina Modolo; Ângelo de Fátima; Luciana Maria Silva; Marcos Derita; Susana Zacchino; Omar Miguel Portilla Zuñiga; Gustavo Pablo Romanelli; Sergio Antonio Fernandes

doi:10.1016/j.bmc.2016.12.023

Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties

Bioorg Med Chem. 2017 Feb 1;25(3):1153-1162. doi: 10.1016/j.bmc.2016.12.023. Epub 2016 Dec 21.

Affiliations

¹ Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil.
² Grupo de Estudos em Bioquímica de Plantas (GEBioPlan), Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
³ Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
⁴ Laboratório de Biologia Celular, Fundação Ezequiel Dias, Belo Horizonte, MG, Brazil.
⁵ Farmacognosia, Facultad de Ciencias Bioquimicas y Farmacuticas, Universidad Nacional de Rosario, Argentina.
⁶ Centro de Investigación y Desarrollo en Ciencias Aplicadas 'Dr. Jorge J. Ronco' (CINDECA-CONICET-CCT-La Plata), Universidad Nacional de La Plata, Calle 47 No. 257, B1900AJK La Plata, Argentina.
⁷ Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG 36570-900, Brazil. Electronic address: santonio@ufv.br.

PMID: 28041802
DOI: 10.1016/j.bmc.2016.12.023

Abstract

An efficient method for the synthesis of quinolines using microwave irradiation was developed providing 28 quinolines with good yields. The reaction procedures are environmentally friendly, convenient, mild and of easy work-up. Quinolines were evaluated for their antifungal, anticancer and antioxidant properties and exhibited high activities in all tests performed.

Keywords: Anticancer; Antifungal; Antioxidant; Calix[n]arenes; Quinoline.

MeSH terms

Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Cell Line
Cell Proliferation / drug effects
Cryptococcus neoformans / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Free Radical Scavengers / chemical synthesis
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology*
Humans
Microbial Sensitivity Tests
Microwaves*
Molecular Structure
Quinolines / chemical synthesis
Quinolines / chemistry
Quinolines / pharmacology*
Structure-Activity Relationship

Substances

Antifungal Agents
Free Radical Scavengers
Quinolines