Update on the use of immunoglobulin in human disease: A review of evidence

Elena E Perez; Jordan S Orange; Francisco Bonilla; Javier Chinen; Ivan K Chinn; Morna Dorsey; Yehia El-Gamal; Terry O Harville; Elham Hossny; Bruce Mazer; Robert Nelson; Elizabeth Secord; Stanley C Jordan; E Richard Stiehm; Ashley A Vo; Mark Ballow

doi:10.1016/j.jaci.2016.09.023

Update on the use of immunoglobulin in human disease: A review of evidence

J Allergy Clin Immunol. 2017 Mar;139(3S):S1-S46. doi: 10.1016/j.jaci.2016.09.023. Epub 2016 Dec 29.

Authors

Affiliations

¹ Allergy Associates of the Palm Beaches, North Palm Beach, Fla. Electronic address: eperez@pballergy.com.
² Department of Pediatrics, Section of Immunology Allergy and Rheumatology, Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine, Houston, Tex.
³ Department of Pediatrics, Clinical Immunology Program, Children's Hospital Boston and Harvard Medical School, Boston, Mass.
⁴ Department of Pediatrics, Allergy, Immunology and BMT Division, Benioff Children's Hospital and University of California, San Francisco, Calif.
⁵ Department of Pediatrics, Pediatric Allergy and Immunology Unit, Children's Hospital and Ain Shams University, Cairo, Egypt.
⁶ Departments of Pathology and Laboratory Services and Pediatrics, University of Arkansas, Little Rock, Ark.
⁷ Department of Pediatrics, Allergy and Immunology, Montreal Children's Hospital and McGill University, Montreal, Quebec, Canada.
⁸ Department of Medicine and Pediatrics, Division of Hematology and Oncology and Stem Cell Transplantation, Riley Hospital, Indiana University School of Medicine and the IU Melvin and Bren Simon Cancer Center, Indianapolis, Ind.
⁹ Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit, Mich.
¹⁰ Nephrology & Transplant Immunology, Kidney Transplant Program, David Geffen School of Medicine at UCLA and Cedars-Sinai Medical Center, Los Angeles, Calif.
¹¹ Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, Calif.
¹² Transplant Immunotherapy Program, Comprehensive Transplant Center, Kidney Transplant Program, Cedars-Sinai Medical Center, Los Angeles, Calif.
¹³ Department of Pediatrics, Division of Allergy & Immunology, University of South Florida, Morsani College of Medicine, Johns Hopkins All Children's Hospital, St Petersburg, Fla.

PMID: 28041678
DOI: 10.1016/j.jaci.2016.09.023

Abstract

Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted.

Keywords: IGIV; IVIG; Immune globulin; SCIG; adverse events; autoimmunity; immune modulating; immunoglobulin; immunomodulation; primary immunodeficiency; transfusion.

Publication types

Review

MeSH terms

Animals
Evidence-Based Medicine
Humans
Immunity, Humoral
Immunoglobulins / therapeutic use*
Immunoglobulins, Intravenous / therapeutic use*
Immunologic Deficiency Syndromes / immunology
Immunologic Deficiency Syndromes / therapy*
Immunomodulation
Injections, Subcutaneous
Practice Guidelines as Topic

Substances

Immunoglobulins
Immunoglobulins, Intravenous