Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

PLoS One. 2016 Dec 30;11(12):e0168632. doi: 10.1371/journal.pone.0168632. eCollection 2016.

Abstract

Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using histogram analysis. Twenty-fifth, 50th and 75th percentile values were calculated and were analyzed for association with microvessel density (MVD), vascular endothelial growth factor (VEGF) and conventional prognostic factors. Correlation between MVD and ve50 was positive (r = 0.33). Ktrans50 was higher in tumors larger than 2 cm than in tumors smaller than 2 cm. In multivariate analysis, Ktrans50 was affected by tumor size and MVD with 12.8% explanation. There was significant association between Ktrans50 and tumor size and MVD. Therefore we conclude that DCE MRI perfusion parameters are potential imaging biomarkers for prediction of tumor angiogenesis and aggressiveness.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / metabolism*
  • Carcinoma, Ductal / metabolism
  • Carcinoma, Ductal / pathology
  • Contrast Media / administration & dosage*
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods
  • Middle Aged
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / pathology*
  • Perfusion / methods
  • Prognosis
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Biomarkers
  • Contrast Media
  • Vascular Endothelial Growth Factor A

Grants and funding

This study was supported by the Research Fund of Seoul St. Mary’s Hospital, The Catholic University of Korea and by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning(2014R1A1A3049554). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.