Cutaneous extranodal NK/T-cell lymphoma mimicking cellulitis an HIV positive patient without lymphopenia

J Cutan Pathol. 2017 Mar;44(3):296-299. doi: 10.1111/cup.12885. Epub 2017 Feb 2.

Abstract

We present the case of a 28-year-old male with a history of human immunodeficiency virus (HIV) with a 1-month history of a steadily enlarging, firm painful lesion on the right posterior shoulder. The patient was initially treated for cellulitis given his clinical picture. Histopathologic examination revealed an angiocentric and dermal proliferation of markedly atypical lymphoid cells with numerous mitoses and apoptotic bodies along with broad zones of necrosis. Biopsy revealed the presentation to be consistent with NK/T-cell lymphoma. The cutaneous lesions from NK/T-cell lymphoma can often be initially mistaken for cellulitis, therefore this malignancy should be included on the differential in a patient HIV/acquired immune deficiency syndrome (AIDS).

Keywords: HIV; NK/T-cell lymphoma; cutaneous lymphoma; extranodal lymphoma; non-Hodgkin's lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Cellulitis / pathology
  • Diagnosis, Differential
  • HIV Infections / complications*
  • Humans
  • Immunohistochemistry
  • Lymphoma, Extranodal NK-T-Cell / diagnosis*
  • Lymphopenia
  • Male
  • Skin Neoplasms / pathology

Substances

  • Biomarkers, Tumor